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Last updated 3 days ago
Melatonin receptor 1A variants as genetic cause of idiopathic osteoporosis | Science Translational Medicine
3 days ago
MTNR1A loss-of-function variant rs374152717 impairs bone turnover and provides evidence of a...
High-fidelity PAMless base editing of hematopoietic stem cells to treat chronic granulomatous disease | Science Translational Medicine
3 days ago
Versatile PAMless CRISPR base editors enable efficient and precise therapeutic correction of...
Follistatin drives neuropathic pain in mice through IGF1R signaling in nociceptive neurons | Science Translational Medicine
3 days ago
After nerve injury, follistatin is up-regulated and interacts with IGF1R to activate...
Human OX40L–CAR-Tregs target activated antigen-presenting cells and control T cell alloreactivity | Science Translational Medicine
3 days ago
Human FOXP3 promoter–driven OX40L–CAR-Tregs potently suppress alloreactivity and control graft-versus-host disease.
Intraoperative evaluation of tumor margins using a TROP2 near-infrared imaging probe to enable human breast-conserving surgery | Science Translational Medicine
3 days ago
Nuclide and optical probes targeting TROP2 support the identification of margins during...
A proinflammatory stem cell niche drives myelofibrosis through a targetable galectin-1 axis | Science Translational Medicine
10 days ago
Unraveling the cancer-stroma interactome in myelofibrosis reveals galectin-1 as an actionable target.
Decreased mitochondrial creatine kinase 2 impairs skeletal muscle mitochondrial function independently of insulin in type 2 diabetes | Science Translational Medicine
10 days ago
Mitochondrial creatine kinase 2 is decreased in type 2 diabetes, which impairs...
A multispecific antibody against SARS-CoV-2 prevents immune escape in vitro and confers prophylactic protection in vivo | Science Translational Medicine
10 days ago
Multispecific antibodies to SARS-CoV-2 increase pseudovirus neutralization breadth and potency and inhibit...
Sleep-sensitive dopamine receptor expression in male mice underlies attention deficits after a critical period of early adversity | Science Translational Medicine
10 days ago
Reversible attention deficits after early adversity are mediated by sleep across species.
An altered natural killer cell immunophenotype characterizes clinically severe pediatric RSV infection | Science Translational Medicine
10 days ago
Increased airway NK cells, altered circulating NK cell immunophenotype, and cytotoxic dysfunction...
Dynamic structural remodeling of LINC01956 enhances temozolomide resistance in MGMT-methylated glioblastoma | Science Translational Medicine
17 days ago
Temozolomide resistance in MGMT-methylated glioblastoma is mediated by a CHK1/DDX46 axis that...
Glucocorticoids induce a maladaptive epithelial stress response to aggravate acute kidney injury | Science Translational Medicine
17 days ago
Glucocorticoid receptor activation in renal tubular epithelial cells amplifies DNA damage, impairs...